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Receptor-binding domain of SARS-CoV spike protein: Soluble expression in E

Toxicity evaluations demonstrate an IC50 above 300 g/mL for joint cells and no adverse effects in 28-day in vivo studies

Signs in infants and young children (often appearing around 4-6 months): Irritability and sleep disturbances Developmental delays or regression Poor muscle tone and coordination problems Speech difficulties White matter abnormalities on brain imaging In adults: Movement disorders Balance and coordination problems Cognitive decline and memory loss Mood changes The symptoms can range from mild behavioral changes to severe, progressive neurological deterioration

& Coats, J