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While thalassemia can be managed by lifelong blood transfusions and iron chelation therapy, or potentially cured by bone marrow transplantation or cord blood transfusions, none of these interventions are without side effects including neurotoxicity, cancer, and even death (Noe 2010

A major limitation to studying GSH metabolism in HSC/MPPs has been the inability to measure quantitatively GSH concentrations in small numbers of HSC/MPPs

But those trials were conducted in HIV-infected patients with lipodystrophy

Acknowledgments The authors thank professor Haibo Mu who provided helpful comments for revising the paper