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When too much of a stimulant or multiple stimulants are used, a person may experience extreme effects that are basically the opposite of an overdose on depressants, which may include the following: Hallucinations Paranoia Agitation and irritability Hyperthermia Increased respiratory rate Rapid pulse Heart palpitations Chest pain Dehydration Rapid eye movement Compulsive or repetitive behaviors Restlessness Muscle spasms Trembling and shakiness If a person overdoses on a stimulant, the most significant risks to their health are dehydration, hyperthermia, stroke, seizures, and heart attack