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Managing nicotine withdrawal is an essential aspect for individuals undergoing detoxification

Nicotine stimulates differentiation and specialization of cells in kidneys, the proliferation of mesangial cells, and fibronectin production, mediated through PKC activation, ERK1/2 phosphorylation, and NADPH oxidase and ROS generation [252, 292,293,294]

With the much lower exposure estimate of Jamrozik (11%), the attributable fractions would be 1.3% and 2.0% in men and women, respectively