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An increased ratio of succinate to -KG in cancers resulting from impaired succinate dehydrogenase (SDH) activity is related to pervasive DNA hypermethylation, which contributes to the downregulation of key genes implicated in cell differentiation and cancer stages 102

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The fat body, while analogous, lacks the structural organization and cellular make-up of the mammalian liver

It is noteworthy that the functional effects of the lactate-lactylation axis vary depending on cell type, disease stage, and metabolic state, with disease-specific core mechanisms and targets that avoid overgeneralization of the lactylation pathway