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It can also enhance intestinal barrier function and reduce inflammation in high-fat diet-fed mice by suppressing the TLR4/NF-B pathway, and by increasing the Bacteroidetes / Firmicutes ratio while reducing the abundance of genera such as Alistipes , Lachnospiraceae_NK4A136_group , and Romboutsia

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Age-Related Phenotype Improvement Preliminary Research Remarkable studies in naturally aged mice demonstrate that FOXO4-DRI treatment produces observable improvements in multiple age-related phenotypes including restored fitness and physical activity levels, improved fur quality and density, and enhanced kidney function markers

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