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It Concentrates Where You Need It Most Once absorbed, ergothioneine is transported via OCTN1 and concentrates in tissues most vulnerable to oxidative stress: Erythrocytes (red blood cells) Eye lens Liver and kidney Brain (particularly mitochondria and nucleus) Skin Bone marrow and semen This preferential accumulation in stress-vulnerable tissues strongly supports its protective role

Most insecticides are metabolised by glutathione conjugation

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As a key antioxidant transcription factor, Nrf2s interaction with ferroptosis illustrates its critical role in regulating oxidative stress and cellular fate