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10.1101/gad.12.7.982 Summary Keywords animal models, pharmacological treatments, metabolic syndrome, obesity, non-alcoholic fatty liver disease, non-alcoholic steatohepatitis, steatosis Citation Peng C, Stewart AG, Woodman OL, Ritchie RH and Qin CX (2020) Non-Alcoholic Steatohepatitis: A Review of Its Mechanism, Models and Medical Treatments

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4.1 Loss of gray matter, white matter, and hippocampal volume The loss of GM, WM, and hippocampal volume, as well as WMLs, is believed to underlie DM-associated cognitive dysfunction (100)

Rising levels of NAPQI in the liver cause widespread damage, including lipid peroxidation, inactivation of cellular proteins, and disruption of DNA metabolism (Bessems 2001)