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Direct infection of pituitary or adrenal tissue, direct damage to the adrenal gland or pituitary caused by the immune system due to antibody production and/or cell damage, and inhibition of the HPA axis induced by inflammatory cytokines (functional hypopituarism) ( Supportive of direct infection, angiotensin-converting enzyme 2 (ACE2) is the receptor used by SARS-CoV2 to infect cells and is expressed in a large number of tissues, including the adenohypophysis ( Regarding direct damage due to the immune system, it has been suggested that there is a high molecular similarity between SARS-CoV-2 peptides and human adrenocorticotropic hormone, as in the case of SARS-CoV viral peptides that are structurally similar to adrenocorticotropic hormone (ACTH) ( Finally, in terms of inhibition induced by inflammatory cytokines, chronic exposure to proinflammatory cytokines such as TNF-, could suppress pituitary ACTH secretion and thus, cause relative hypocortisolism during chronic infections ( 3 Hypopituitarism in myalgic encephalomyelitis Something similar could happen in patients with myalgic encephalomyelitis or chronic fatigue syndrome (ME/CFS), where lower ACTH levels at 6 months after diagnosis of EBV induced infectious mononucleosis were highly predictive of the development of ME/CFS ( In the study by Steiner et al
and managing lifestyle factors which impact on the immune system, such as stress, sleep and chemical exposure
What assay formats are used to confirm Trevogrumab's neutralizing potency against myostatin-induced signaling
