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Female genital tuberculosis (FGTB) is a clinically silent chronic disease that primarily involves the fallopian tubes in nearly all cases, leading to infertility, dyspareunia, menstrual irregularities, and chronic pelvic inflammation (Namavar et al., 2001)

Immune activation in orthotopic osteosarcoma mouse model Cell experiments demonstrated that H 2 O 2 generated by NP4 could activate macrophages and mediate immune responses

Cleavage of Boc groups with 4 M HCl/dioxane followed by a coupling reaction with the -carboxyl group of the N -hydroxysuccinimide active ester of Boc-Glu--OtBu resulted in the corresponding glutathione disulfide-1,1- 13 C with fully protected N and C-terminals

The second stage is Trem2-dependent and is marked by increased expression of genes involves in lipid metabolism and phagocytic pathway genes (e.g., Lpl, Cst , and Cd9 ), causing excessive inflammatory responses and neurodegeneration (Keren-Shaul et al., 2017