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Nevertheless, several follow-up studies have reaffirmed DHODHs ferroptosissuppressive function under specific metabolic or oxidativestress conditions 93,94,95,96 , supporting the notion of a contextdependent mechanism rather than a universally essential role

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The latter, through the formation of ROS, cause direct membrane damage triggering the genesis of a vicious circle inflammatory process that underlies the pathogenesis of AD (17)