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The vascular improvements may enhance BDNF delivery to brain regions by improving blood flow to the hippocampus and cortex

Central Role of Glycine in Overall Metabolism Glycine, outside the context of protein synthesis and of its role as an inhibitory neurotransmitter, serves a critical role as an integrator and regulator of numerous metabolic pathways that includes, but is not limited to, heme biosynthesis, glutathione (GSH) biosynthesis, creatine biosynthesis, and overall one-carbon metabolism

However, the mean age of their subjects was a relatively young 38.5 years and most of the studies involved short-term follow-up

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