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Supplementing B12 will only make a difference if you have insufficient or deficient levels of B12, she tells GQ

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Vitamin B6 deficiency, anemia (lack of red blood cells), peripheral neuropathy (nerve problem), seizures (fits), and inherited conditions including hyperoxaluria (high oxalate levels in urine) and homocystinuria may all be treated and prevented with it (accumulation of an amino acid called homocysteine in urine and blood)

When taking B12 via injections or high doses of supplements, it bypasses the absorption limits of dietary B12, leading to a temporary rise in blood B12 levels