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Malabsorption: Cells in the stomach known as parietal cells create an intrinsic factor protein essential for B12 absorption

A favorable response has been noted with calcineurin inhibitors, oral corticosteroids, oral polypodium leucotomas, and afamelanotide whereas inconsistent results were found with vitamin D3 analogs and topical pseudocatalase

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An animal model with different genes knocked out could be generated and imaged with GluCEST to understand better the effect of the gene mutation on regional alterations in the brains glutamate level