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Reduced ability to recover from spindle disruption and loss of kinetochore spindle assembly checkpoint proteins in oocytes from aged mice

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The reaction people describe as "ruined" is almost always the "copper uglies," a temporary inflammatory adjustment phase that resolves within 2 to 6 weeks when use is reduced or paused and the barrier is supported

They are particularly beneficial for vegetarians and vegans (since B12 is found primarily in animal products), older adults with reduced absorption capacity, individuals with digestive conditions such as Crohn's disease or celiac disease, and anyone who has had gastric bypass surgery