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Bupropion yields better results than Varenicline when combined with nicotine replacement therapy and using both Varenicline and Bupropion at the same time does not increase the success rate of quitting smoking nor does it show any substantial benefits.

To put these findings in context, if a woman smoked a pack of cigarettes a day for three years, the loss of forced vital capacity would correspond roughly in size to 46 ml

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