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The angiogenesis hypothesis may provide new insights by suggesting a decline in angiogenic growth factors with age, which in turn leads to a reduction in microcirculation in the body (Ambrose 2016)

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Interestingly, the pH optimum of the enzyme detected in barley roots was reported to be higher than seven, which suggests that the activity could increase in conditions that induce alkalinisation of the apoplast (Ferretti et al., 2009)