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Meanwhile, IL6 can promote migration and invasion by inducing the expression of matrix metalloproteinases (MMPs) and activating epithelial-mesenchymal transformation 35

Optimization strategies for both treatments involve personalized dosing, regular GH level monitoring, and lifestyle modifications to maximize results while minimizing side effects

The recent discovery of pharmacological ABHD5 ligands that disrupt the interaction between ABHD5 and PLIN1 (48) demonstrate that the dissociation of ABHD5 is sufficient to stimulate adipocyte lipolysis and that these protein interactions can be targeted pharmacologically (34, 48, 49)

Enzyme function is also compromised by copper deficiency, including that of copper-zinc SOD (Cu-Zn SOD), resulting in a weakened antioxidant defence system and increased vulnerability to oxidative stress, contributing to the development of atherosclerosis (103)