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Another pair of families is the 1-Cys and 2-Cys peroxiredoxins (Prxs) (Copley et al., The vast database of sequenced genomes of organisms is a valuable resource which can be mined for information regarding the evolution of these pathways, leading to a better understanding of their function and control

the presence of key substrates for peroxidation, i.e., phospholipids with polyunsaturated fatty acyl termini and diallyl carbons that are susceptible to peroxidation [For example, the classical pathway mediated by ALOXs (195) or POR (196) and the non-classical pathway mediated by the peroxisome-ether-phospholipid axis (197) act on the peroxidation of PUFAs] (3)

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Two notable trials involved the application of Argireline on one side of the face and an empty vehicle as a placebo on the other