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It is primarily studied for its ability to upregulate telomerase activity, the enzyme responsible for rebuilding telomeres (the protective caps at the ends of chromosomes)

Western blot analysis of thoracic aorta proteins showed that the classic aging markers P21 and P16 were significantly downregulated following FOXO4-DRI treatment, whereas the expression levels of the cell proliferation marker Ki-67 and Lamin B, a key protein involved in nuclear structural stability, were markedly upregulated (Figure 1A)

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