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172 PROM2 regulates endocytosis, and its overexpression leads to significant changes in plasma membrane organization and function, including increased cellular pseudopodia, which has invasive potential and is a potential biomarker for predicting distant metastasis and decreased survival

Furthermore, FoxO3a can bind to PINK1 and Parkin gene promoter and upregulate their expression to enhance mitophagy (Zheng et al., 2019

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SARS-CoV-2 spike protein disrupts bloodbrain barrier integrity via RhoA activation