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The prefrontal cortex is highly sensitive to DA and even minor fluctuations can impair prefrontal cortex-dependent functions, making it particularly relevant in PTSD, as it plays a central role in suppressing fear responses, regulating stress reactivity, and enabling emotional control ( 3.4.4 Gut microbiota-based therapeutic interventions 3.4.4.1 Probiotics Therapeutic targeting of the gutbrain axis shows promise for PTSD treatment across multiple intervention modalities