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These proteins exist in three subtypes: SREBP-1a, SREBP-1c, and SREBP-2, each contributing to distinct metabolic pathways ( Peroxisome proliferator-activated receptor-alpha (PPAR-) serves as a pivotal transcription factor that orchestrates the transcriptional regulation of genes containing peroxisome proliferator response elements (PPREs) (Yamazaki et al., 2025)

These properties have made phytomedicine an important area in anti-EMs drug development, offering not only symptomatic relief but also mitochondria-directed interventions that may restore bioenergetic function, reduce oxidative stress, rebalance fission-fusion dynamics, remove damaged organelles through mitophagy, and reactivate mitochondrial biogenesis (Yu Y

PHGDH inhibits ferroptosis and promotes malignant progression by upregulating SLC7A11 in bladder cancer

Glutathione synthesis is compromised in erythrocytes from individuals with HIV