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The theoretical and methodological approach was the same one that would be used in later studies by this group: "Since the DSM-IV definition of nicotine dependence does not allow for the possibility that dependence might start before "prolonged heavy use", the DSM-IV criteria were not used in this study

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Biological intermediates as transducers of systemic effects In addition to exposure, the development of biological intermediates also needs special attention (145, 153, 163168)

However, it is not a guaranteed solution and should not be considered a replacement for other smoking cessation methods such as nicotine patches or gum