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Free vitamin C (ascorbic acid) did not protect against liver or kidney damage in mouse models (Jonker 1988

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PMID 29898649 Sikiric P, Seiwerth S, et al

For example, mitophagy mediated MQC heavily depends on efficient lysosome degradation, whose dysregulation reversely suppresses mitochondrial function, so they all interplay by each other to form a vicious cycle, participating in the pathogenesis of neurodegenerative diseases