If left untreated, it can lead to Heart palpitations and shortness of breath Weakness, tiredness, or lightheadedness Pale skin Vision loss Constipation, diarrhea, loss of appetite, or gas A smooth tongue Depression Memory loss Behavioral changes Numbness or tingling Muscle weakness Problems walking not trying to give you the wobbles here!), low levels of B12 can be linked to the development of pernicious anemia, dementia, or osteoporosis
Patients with pernicious anaemia, malabsorption disorders (such as Crohn's disease or coeliac disease), or following gastric surgery require regular B12 supplementation to prevent serious complications including megaloblastic anaemia and neurological damage

Proposed explanations include: Tissue retention of peptide or active metabolites Persistent activation of signaling cascades beyond peptide clearance Potential for active metabolites with prolonged tissue residence Excretion Pathways Limited data on elimination routes indicates: Likely renal excretion of peptide fragments based on molecular weight and water solubility Potential hepatic contribution to metabolite clearance No evidence of accumulation in chronic dosing studies in rats and monkeys Degradation products eliminated without evidence of toxic metabolite formation The dramatic disconnect between three-minute plasma half-life and prolonged metabolic effects remains one of the most intriguing and poorly understood aspects of AOD-9604 pharmacology, requiring further mechanistic investigation

Some foods high in vitamin B may include: milk cheese eggs liver and kidney meat, such as chicken and red meat fish, such as tuna, mackerel, and salmon shellfish, such as oysters and clams dark green vegetables, such as spinach and kale vegetables, such as beets, avocados, and potatoes whole grains and cereals beans, such as kidney beans, black beans, and chickpeas nuts and seeds fruits, such as citrus, banana, and watermelon soy products, such as soy milk and tempeh blackstrap molasses wheat germ yeast and nutritional yeast Most people get enough B vitamins by eating a balanced diet