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25 In some cases, neuropathy symptoms are preceded by the onset of gastrointestinal symptoms, or they may occur in isolation

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Similarly, chemogenetic activation of this circuit reversed morphine-induced constipation in mice, including significantly increased the output and water content of feces, as well as a significant higher transit rate and motility of the small intestine in hM3Dq-expressing mice than mCherry-expressing controls (Supplementary Fig

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