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So, why does this cross-reactivity happen

In this double-blind, placebo-controlled study, patients with PTSD ( N = 100

J Biol Chem 270:14811484 Ursini F, Maiorino M, Brigelius-Flohe R, Aumann KD, Roveri A, Schomburg D, Flohe L (1995) Diversity of glutathione peroxidases

This is because reducing inflammation doesnt directly inhibit 5-alpha reductase, but rather, inhibits the inflammation that signals 5-alpha reductase to arrive in certain tissues (like our scalp skin and prostates)