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Oxidative modifications of mitochondrial complex II are associated with insulin resistance of visceral fat in obesity

In some embodiments, dyes that are compatible with the otic compositions described herein include Evans blue (e.g., 0.5% of the total weight of an otic formulation), Methylene blue (e.g., 1% of the total weight of an otic formulation), Isosulfan blue (e.g., 1% of the total weight of an otic formulation), Trypan blue (e.g., 0.15% of the total weight of an otic formulation), and/or indocyanine green (e.g., 25mg/vial)

Thus, with an estimated worldwide population of 7.3 billion, nearly one billion people are likely to suffer acute and/or chronic wounds (in the USA, 6.5 million people suffer from chronic wounds) [3]

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