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Crucially, the researchers noted that the S-A-GSH molecule was rapidly deacetylated once inside the body, proving that the acetyl shield successfully protected the compound through the digestive tract and then efficiently released the intact, active glutathione directly into the intracellular environment where it is needed to combat oxidative stress

The higher demand of S in leaves during stress is probably required to support the synthesis of defense and signaling metabolites

They consider pros and cons, and substitutes

Each purification pass adds cost but removes contaminants that could affect safety or efficacy