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The most practical approach for many protocols involves starting with a 5mg vial for the early escalation phases and switching to a 10mg vial once weekly doses are higher

Syringe units measure liquid volume

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In addition to multifocal lesions in MS, in a recent study using fluorescence spectroscopy using the solvatochromic lipid probe Nile Red, we reported diffuse changes in myelin lipid polarity in otherwise normal-appearing MS white matter, which was particularly pronounced in the periventricular areas, again supporting the notion of a myelin toxin circulating in the CSF