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NNMT inhibition in cell culture models has been associated with enhanced myogenic commitment, suggesting that the same NAD+/SAM preservation mechanism that restores adipocyte energy expenditure may also support muscle regeneration processes

First, the causal direction in human studies remains ambiguous: it is unclear whether gut dysbiosis is a driver of OA or a consequence of its associated factors, such as reduced physical activity, diet changes, or chronic medication use

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Protein folding theory: from lattice to all-atom models