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These, along with pollution and other external elements such as stress, can cause premature ageing of the skin due to oxidative stress that usually manifests itself in visible signs such as wrinkles, dark spots, loss of firmness

If these measures do not work, an over-the-counter osmotic laxative like polyethylene glycol (MiraLAX) can be used daily as needed

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The GPX family contains eight members (GPX1-GPX8), of which GPX1-GPX4 and GPX6 (human) members have an active center of selenocysteine, which is an important selenoprotein in mammals (Table 1)