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In eukaryotes there are two species of SOD enzyme, copper-zinc SOD and manganese SOD (SOD CuZn and SOD Mn )

Bibcode:2000MRRMR.463..247L

From the several sites that can generate superoxide in the mitochondrial matrix, only the superoxide produced at complex III appears to be released both into the matrix and the IMS (Quinlan et al., 2013)

In addition, in an in vitro model of PC12 cell neurotoxicity, studies have demonstrated that curcumin can protect PC12 cells from the inhibition of cisplatin without compromising cisplatins anticancer activity [126]