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Biomedicines 10 , 2693 (2022)

Unlike single-pathway compounds, retatrutide simultaneously activates three distinct receptor systems: GIP (glucose-dependent insulinotropic polypeptide), GLP-1 (glucagon-like peptide-1), and glucagon receptors [3]

Separate studies delved directly into the brain to look for tell-tale signs with bi-polar: Postmortem studies of patients with BD revealed reduced expression of NMDAR subunit NR1 in the prefrontal cortex (44) and reduced expression of several NMDA, AMPA, and kainite receptor subunits in the medial temporal cortex Again, pointing to reduced glutamate at the NMDA receptor

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