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Because of the limited efficacy of CB-839 as a single agent, combinations of CB-839 with venetoclax, AZD-5991, and ibrutinib were assessed using the Loewe synergy model

Skin and Other Effects: Very rarely, severe skin rashes or abdominal pain have been reported

Mouse serum analysis Mice were anaesthetized with isoflurane, after which blood was collected via the retro-orbital venous sinus into BD microtainer tubes (BD, 365967)