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CELLULAR ORIGIN OF GASTRIC CANCER INDUCED BY HP Gastric carcinomas are generally believed to evolve from native gastric mucosa or intestinal metaplastic mucosa that undergoes various genetic and epigenetic alterations involving either the suppressor pathway defects (defects in tumor suppressor genes) or the mutation pathway (defects in DNA mismatch repair gene) (112)

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Zack TI, Schumacher SE, Carter SL, Cherniack AD, Saksena G, Tabak B, et al

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