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Additionally, a randomized, double-blind, placebo-controlled trial in 2,588 healthy older adults with mild hyperhomocysteinemia found that daily supplementation with 500 g of vitamin B 12 and 400 g of folic acid for two years reduced blood homocysteine concentrations but had no benefit on depressive symptoms in those with or without depressive symptoms at baseline (110)

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If you have pernicious anemia, make sure youre using the methylcobalamin form of B12

This makes it of particular interest in studies targeting body recomposition and long-term metabolic efficiency, where muscle retention is critical for sustaining basal metabolic rate