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Huge gastrocutaneous fistula leaking at 1st postoperative day in control rats ( c ) and dried fistula without any leakage in BPC 157 rats ( b (Skorjanec et al., 2009)

Although tachyphylaxis to this effect may occur with long-acting GLP-1 receptor agonists, GLP-1-associated slowing of gastric emptying does not appear to be responsible for the nausea and vomiting often reported with the use of GLP-1 receptor agonist treatment