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Long-term administration of the anti-inflammatory drug roflumilast to mice with secretory immunoglobulin A (SIgA) immunodeficiency due to polymeric immunoglobulin receptor (pIgR) deficiency prevents progressive tracheal wall remodeling and partial reversal of emphysematous alterations in SIgA-deficient mice

In Achilles transection and ligament injury models, it counteracts corticosteroid impairment, elevates collagen deposition, and increases biomechanical strength

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