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We reviewed Sikiric 1993-2026 (Zagreb, over 150 BPC-157 papers), the AJSM 2026 systematic review (35 preclinical studies), the 2026 pilot PK study in two healthy subjects, and the February 2026 STAT review

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It was noted that IGF-1 activated steroidogenic and apoptotic regulatory genes through activation of PI3K/Akt pathway in bovine granulosa cells (70, 71)

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