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Furthermore, increasing aging population and chronic diseases prevalence demand the development and implementation of antioxidant therapies in clinical practice

Pathogenesis of Kupffer cells in cholestatic liver injury

YC-1, an early identified HIF inhibitor, operates by diminishing the expression of HIF-1 target genes, including VEGF and inducible nitric oxide synthase (iNOS), through suppression of HIF-1 stability and transcriptional activity under hypoxic conditions, thereby modulating inflammatory responses and vascularization in RA (211)