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The body of evidence in support of these claims is substantial

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Bilirubin can alleviate hepatic oxidative stress, maintain normal hepcidin function, and upregulate GPX4 to prevent iron overload (Shinn et al., 2024

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FASEB J (2019) 33(11):1228898

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101 As a selective autophagy receptor, p62/SQSTM1, when upregulated in nematodes and Drosophila , can promote protein homeostasis and extend lifespan

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