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Overman MJ, Varadhachary GR, Kopetz S , Adinin R, Lin E, Morris JS, Eng C, Abbruzzese JL, Wolff RA

Experimental models demonstrate that FOXO proteins mediate the inhibitory effects of insulin/IGF on target genes and are essential for maintaining metabolic homeostasis

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Alisol A 24-acetate (AA-24-a), a key triterpenoid in Rhizoma Alismatis, can change fat metabolism-related genes (downregulate HSL, PPAR, and perilipin A, upregulate adipose triglyceride lipase (ATGL)) ( 6.7 Crataegus pinnatifida Bung Crataegus pinnatifida Bunge ( Crataegus pinnatifida Bge