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The early Jamestown settlers followed the Indian custom of planting the tobacco seed in hills as they did corn, although some probably followed the practice as described by Stevens and Liebault's Maison Rustique or The Country Farm , published in London in 1606: For to sow it, you must make a hole in the earth with your finger and that as deep as your finger is long, then you must cast into the same hole ten or twelve seeds of the said Nicotiana together, and fill up the hole again: for it is so small, as that if you should put in but four or five seeds the earth would choake it: and if the time be dry, you must water the place easily some five days after: And when the herb is grown out of the earth, inasmuch as every seed will have put up his sprout and stalk, and that the small thready roots are entangled the one within the other, you must with a great knife make a composs within the earth in the places about this plot where they grow and take up the earth and all together, and cast them into a bucket full of water, to the end that the earth may be separated, and the small and tender impes swim about the water

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37 Similar results have been observed in trials using combination therapy with sustained-release bupropion and the nicotine patch