Indeed, xCT / mice are healthy and fertile despite an increase in cystine plasma concentration and a decrease in GSH plasma level
Importantly, nuclear-localized FOXO4-positive Leydig cells in elderly testes showed reduced expression of 3-HSD, a rate-limiting enzyme in testosterone synthesis, implying a connection between nuclear FOXO4 and age-related decline in testosterone production [1]
HDAC6 Inhibition Mediated Protection from Hepatic Ischemia Reperfusion is Associated with Preserved Glutathione Levels 1 Surgery, University of Pennsylvania, Philadelphia, PA, 2 University of Pennsylvania, Philadelphia, PA, 3 Surgery, University of Pensylvania, Philadelphia, PA, 4 College of Pharmacy, University of Illinois at Chicago, Chicago, IL, 5 Childrens Hospital of Philadelphia, Philadelphia, PA Meeting: 2022 American Transplant Congress Abstract number: 664 Keywords: Glutathione, Ischemia, Liver preservation Topic: Basic Science Basic Science 14 - Ischemia Reperfusion Session Information Session Name: Ischemia Reperfusion Session Type: Poster Abstract Date: Saturday, June 4, 2022 Session Time: 5:30pm-7:00pm Presentation Time: 5:30pm-7:00pm Location: Hynes Halls C & D *Purpose: Liver Ischemia reperfusion injury (IRI) and Acetaminophen (APAP) toxicity are important causes of acute liver failure in the United States, that lack effective therapy
DOI: 10.1016/j.jdiacomp.2007.10.003 57
