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This chapter will present current understanding and controversies surrounding nomenclature and definition of the disorder, pathogenesis, and diagnostic approach

Severe or concerning symptoms warrant medical attention and discontinuation of use

Since oxidative stress is the main cause of APAP-induced hepatotoxicity, sulforaphane protects the liver from APAP overload toxicity by activating the Nrf2 pathway and increasing the endogenous antioxidant response (Schmidt, 1984)

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