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Providing support for a causal link between a negative energy state and increased Parasutterella abundance, a rat model of obesity, which showed similar Parasutterella relative abundances in animals maintained on HFD and those maintained on normal chow but exhibited a treatment-induced increase in Parasutterella relative abundance, displayed a negative correlation between Parasutterella and body weight 82

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It is characterised by its selective interaction with NNMT (Nicotinamide-N-Methyltransferase) , an enzyme implicated in a range of metabolic and biochemical regulatory processes, making it a valuable reference compound for preclinical and in-vitro research programmes

Typically, iron chelation therapy is not the first option for hemochromatosis