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It is used as a tool in *in vitro* models to investigate its effects on the synthesis and breakdown of key ECM components, such as collagen and elastin

Using this cream with other strong topical products such as prescription retinoids (e.g., tretinoin), chemical exfoliants (alpha- or beta-hydroxy acids), or benzoyl peroxide may increase irritation

People with a history of pancreatitis If you have had pancreatitis before, the threshold for recurrence is lower

Joint health supplements safety, side effects and drug interactions: Most of these ingredients can cause some gastrointestinal upset (such as nausea) and, although generally safe, some can interact with drugs (such as those for blood thinning), trigger allergies, or cause other side-effects