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10.1038/s41580-020-0210-7 Nat

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Additionally, they noted that stimulation of LNCaP with 5-LOX-derived eicosanoids, 5-HETE and 5-oxoETE (5-oxo-eicosatetraenoic acid), reversed Se's apoptotic effect and enhanced growth of cancerous cells, thus indicating that 5-LOX-derived eicosanoids may play a role in promoting cancerous cell growth in prostate cancer ( Reference Ghosh 85 )